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Drug-Resistant Candida glabrata Infection in Cancer Patients - CDC
Patients with cancer are often at risk for candidemia because of indwelling .... Drug-Resistant C. glabrata Infection in Cancer Patients. Emerging Infectious ...

Uncommon Candida Species Fungemia among Cancer Patients
Oct 15, 2015 ... among cancer patients in whom uncommon Candida spp. ... Distinguish the most prevalent uncommon Candida infection in the current ... with a higher risk for mortality among patients with candidemia ... temic antifungal drugs for >7 consecutive days; 21 were re- ... C. albicans, C. glabrata, C. parapsilosis,.

The changing epidemiology of invasive candidiasis
Apr 15, 2008 ... Candida Glabrata and Candida Krusei as the Leading Causes of ... ter-related infection as a risk factor for C. parapsilosis candidemia. ... KEYWORDS: epidemiology, candidemia, cancer patient, ... quent and prolonged antibiotic regimens, which tend .... candidemia was catheter-related more often in.

Clinical Practice Guidelines for the Management of Candidiasis
Jan 15, 2004 ... the treatment of candidemia, other forms of invasive candidiasis, ... For infection due to Candida glabrata, an echinocandin is .... ically ill patients with risk factors for invasive candidiasis and ... Antifungal drug resistance, drug- ..... Therapy is often for several months, ..... cancer, and patients with diabetes).

Candidemia - Clinical Infectious Diseases
Oct 4, 1998 ... in nine episodes and Candida glabrata and Candida krusei in two episodes each . Eleven episodes ... ses are well described as occurring in patients infected with ... caused by fluconazole-resistant C. albicans have been reported .... the 13 patients with candidemia, only two were intravenous drug tion.

Candidaemia in adult cancer patients: risks for fluconazole-resistant
Mar 4, 2010 ... Background: Candidaemia in cancer patients is associated with increasing fluconazole resistance. Models for ... Candida glabrata and Candida krusei.4 – 7 This shift is clinically rel- ... Treatment was the antifungal drug received on the day of or after the .... Risk factors for infection with fluconazole-resistant.

candida glabrata: an emerging threat for the immunocompromised
9, No. 1. 115. Candida glabrata infection in immunocompromised patients ... information on drug resistance, in order to pro- ... immuno-compromised, at-risk hospitalized pa- ... increasing cause of candidemia, especially at can- .... occur more frequently in cancer patients, mainly .... is also often resistant to fluconazole. 10,11.

Risk factors for fluconazole-resistant invasive candidiasis in - Life
Results: Forty-one percent of ICI patients were infected with Flu-R Candida. ... stayed in ICU with fluconazole as the first-line drug before testing isolates for drug sensitivity. ... specific disease (such as cancer or liver transplantation), and few stud- ... fluconazole is defined as SDD and resistant for C glabrata, respectively.

The efficacy and tolerability of monotherapy with micafungin for
Mar 17, 2014 ... Departments of 1Infectious Diseases, Infection Control and ... The response rate in 58 patients with cancer and candidemia or deep-seated candidiasis ... safety of micafungin in cancer patients with invasive candidiasis ..... side effects in our patients, who are at high risk for multiorgan failure as well as drug.

Epidemiology and Prognostic Factors of Candidemia in Cancer
Jun 5, 2014 ... ... infections. Among the 242 cancer patients with candidemia, head and neck cancer was the most ... albicans Candida species, including C. tropicalis, C. glabrata, and C. parapsilosis ... malignancy is one of the major risk factors for invasive candidemia .... Moreover, several antibiotic-resistant pathogens.

Efficacy and Tolerability of Micafungin Monotherapy for Candidemia
Feb 8, 2014 ... Department of Infectious Diseases, Infection Control, and Employee ... analysis of candidiasis in cancer patients, response rates for treat- ... owing to drug intolerance or toxicity. ... patients with caspofungin-resistant Candida isolates had re- ..... often have multiple risk factors for kidney injury, such as ad-.

Emergence of Resistant Candida in Neutropenic Patients - SciELO
Though the frequency of resistant strains is still low in neutropenic cancer patients, and is mostly limited to Candida glabrata and Candida krusei, resistance to ...

Coping with Candida Infections - ATS Journals
Jul 23, 2009 ... candidemia, specific interventions further raise the risk of invasive ... candidiasis than do patients with cancer. CANDIDEMIA ... C. glabrata infections are often ..... antifungal resistance profile, relative drug toxicity and any.

Candida tropicalis - Journal of Medical Microbiology
organism's dominance and its resistance to fluconazole have been difficult to ... of patients with fungal infections (Nissapatorn et al., 2003; .... infections, underlying clinical conditions, treatment and outcome in cancer ... C. tropicalis associated with candidiasis is not often .... induced IP-10 expression but C. glabrata did not.

Prevalence, Susceptibility Profile for Fluconazole and Risk Factors
Bloodstream infections caused by yeast, Candida spp, are quite important ... the species (C. glabrata and C. krusei) that tend to be resistant to the azolic ... susceptibility profile to anti-fungal drugs in order to ... investigate the risk factors for candidemia in patients ..... fluconazole for prophylaxis and in neutropenic cancer.

Fungal Infections in the Intensive Care Unit - ACCP
Classify a critically ill patient's risk of invasive fungal infection. 2. Construct a ... In patients with candidemia requiring ICU care, death ... Among non-albicans spp., Candida glabrata and Candida ... However, the intrinsic resistance of C. krusei to fluconazole ..... Comprehensive Cancer Network, include empiric treatment.

The epidemiology, antifungal use and risk - Semantic Scholar
Background: The elderly patients affected by candidemia are growing in proportion to ... Resistance to fluconazole and voriconazole for non-Candida albicans ... cancer, undergoing surgery, and staying in intensive care ... vulnerable to Candida infections [12,13]. ... the recently updated species-specific antifungal drug sus-.

Coping with Stress and the Emergence of Multidrug Resistance in
Mar 19, 2015 ... Because of the high risk of fungal infections in immunocompromised ... In this article, we focus on drug resistance in Candida spp. because of ... al activator of drug efflux pumps is often sufficient to confer high-level azole resistance [26]. .... ( 2014) Drug-resistant Candida glabrata infection in cancer patients.

Fungal Infections in Immunosuppressed Patients - InTech
Candida infections often start at mucosal surfaces, and cell-mediated ... candidiasis reflects the enormous increase in the number of patients at risk and the ... immune deficiency, and those receiving aggressive cancer treatment, ... from patients with candidemia or invasive candidiasis. C glabrata has recently become very.

Multidrug resistance in pathogenic yeasts: emphasis on the role of
Patients infected by C. tropicalis often require longer periods of ..... Tarrand, and D.P. Kontoyiannis, Drug-resistant Candida glabrata infection in cancer patients. ... [49] Hegazi, M., et al., Characteristics and risk factors of candidemia in pediatric  ...

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